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Zhengli Shi: "The novel 2019 coronavirus is nature punishing the human race for

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09 Feb 2020 16:58 #2704 by PrepperBob
Chinese Mad Scientists, Zhengli Shi, Dr Li, Manufactured Wuhan CoronaVirus, and calls everyone in USA "tin foil hat" conspiracy theorists....

Zhengli Shi: "The novel 2019 coronavirus is nature punishing the human race for keeping uncivilized living habits..."

Zhengli Shi’s group at the Institute of Virology at Wuhan was successful in isolating two infectious clones of bat SARS-Like CoV: SL-CoV-WIV1 and WIV16 from bats. In their further studies, they found out that these SL-CoV Spike protein (S protein) “[were] unable to use any of the three ACE2 molecules as its receptor; Second, the SL-CoV failed to enter cells expressing the bat ACE2; Third, the chimeric S covering the previously defined receptor-binding domain gained its ability to enter cells via human ACE2, albeit with different efficiencies for different constructs; Fourth, a minimal insert region ( Amino acids 310 to 518 ) was found to be sufficient to convert the SL-CoV S from non-ACE2 binding to human ACE2 binding.”

Therefore, Shi’s group found in a study published in the Journal of Virology in February 2008 that the natural bat coronavirus cannot use
the human ACE2 receptor to infect humans. However, when inserted with some amino acids from position 310 to 518 for the
bat CoV S protein sequence, the chimeric bat CoV can use the human ACE2 receptor.

Meanwhile, another research group led by Dr. Li published their finding in 2013 that 5 amino acid sites on CoV spike proteins are crucial
in making the binding to human ACE2 on SARS virus (those positions are Y442, L472, N479, D480, T487).
These 5 sites just lie in the region that the Shi group noted to be important above.

Later, Li and Shi jointly conducted a gain-of-function study published in the Journal of Virology in September 2015 on the MERS virus
and a bat virus (strain HKU4) in 2015. Since MERS virus can enter human cells but HKU4 can not, they introduced 2 single mutations
in the HKU4 spike protein and found that the new mutant S protein can enable HKU4 to enter human cells. If they mutated 2 sites in
MERS spike, the resulting MERS pseudovirus (experimental virus) cannot enter human cells anymore.

Furthermore, Shi’s group joined an international group to generate a chimeric virus with the bat virus SHC014
they harvested in Yunnan. Since they know SHC014 is unlikely to bind to human ACE2, they
“synthesized the SHC014 spike in the context of the replication competent, mouse-adapted SARS-CoV backbone”.
So, that is a lab-engineered virus with SARS-CoV Mouse adapted backbone (MA15) but with SHC014 spike.

To their surprise, the chimeric virus (SHC014-MA15) can use SHC014 spike to bind to human ACE2 receptor
and enter human cells. SHC014-MA15 can also cause disease in mice and cause death as well.
Existing vaccines to SARS cannot protect animals from SHC014-MA15 infection.
Therefore, these chimeric virus studies can lead to the generation of more pathogenic, more deadly CoV strains in mammalian models.

Due to the U.S. government-mandated pause on the gain-of-function (GOF) studies, this international research
did not proceed further at that time. However, there is no evidence that Shi’s group in China stopped any further study
on the track of introducing GOF mutations on the CoV. And it is clear that Shi’s group already mastered
the reverse-engineering technology that is sufficient to introduce mutation in
current SARS-CoV or SARS-Like CoV to create mutant infectious coronavirus.

[ZH: In February 2020, the South China Morning Post reported that Shi's decade-long work to build up one of the world's largest databases of bat-related viruses gave the scientific community a "head start" in understanding the virus. The SCMP also reported that Shi was the focus of personal attacks in Chinese social media who claimed the WIV was the sources of the virus, leading Shi to post: "I swear with my life, [the virus] has nothing to do with the lab", and when asked by the SCMP to comment on the attacks, Shi responded: "My time must be spent on more important matters."

Caixin reported Shi made further public statements against "perceived tinfoil-hat theories about the new virus's source", quoting her as saying:

"The novel 2019 coronavirus is nature punishing the human race for keeping uncivilized living habits..."]
*SARS, HIV, Gain of Function (GOF), and synthetic material were SPLICED into the CoronaVirus. Confirmed.
*This clearly shows the PATH the Mad Chinese Scientists took to WEAPONIZE the CoronaVirus. Confirmed.
*Further proof is that China, President Xi, REFUSE to give samples to the USA. Over 2 months now, ENDANGERING the World.
*Millions could die, because of these Mad Scientists, the Chinese Government's delays in reporting, refusal to disclose the facts, hand over samples.

Will this lead to a World War with China???

Zhengli Shi: "The novel 2019 coronavirus is nature punishing the human race for keeping uncivilized living habits..."

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09 Feb 2020 22:04 #2708 by JackParr68
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13 Feb 2020 04:09 #2731 by PrepperBob
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